Main Board vs. SME: Understanding the Key Differences for Investors Main Board vs. SME: Understanding the Key Differences for Investors When navigating the stock market, understanding the difference between the Main Board and the SME (Small and Medium Enterprises) Board is essential. Kiran Shroff / Friday, January 31, 2025 / Article rating: 5.0 Both offer unique investment opportunities, but the companies listed on each differ in terms of size, market maturity, and regulations.